Tuning in…
Tuning in…
Desert Island Discs
Presented by Sue Lawley
A pioneering heart transplant surgeon who performed a controversial baboon experiment and achieved a 90% success rate.
Eight records
Prelude and Fugue No. 1 in C major, BWV 846
I find the music of Bach very, very soothing, and it sounds very, very simple, and yet it's absolutely perfect in every way, mathematically.
I didn't understand Bob Marley initially and it was my son who was playing Bob Marley and it took me some time to understand this music and then when I did, I found that it's an extremely sensitive person with lovely music which tackles a lot of human issues.
Vienna Philharmonic and State Opera Chorus, conducted by István Kertész
the confitante is representing this terrific agitation of the soul or something which only Mozart can depict.
Vienna Philharmonic and State Opera Chorus, conducted by István Kertész
this is a very peaceful, thoughtful piece of music.
Vienna Philharmonic, conducted by James Levine
Tchaikovsky is again a very sensitive musician and he created this music with three or four dancers dancing and that to me represents human elegance in a very big way.
Wir setzen uns mit Tränen nieder
Chicago Symphony Orchestra and Chorus, conducted by Sir Georg Solti
I heard my own daughter singing in the choir. I was so moved that that piece of music has just stuck in my mind and will forever.
I find his serenade as representative of that extremely beautiful attribute.
Mozart has many facets as we have heard, but at times he can be very thoughtful and I think that in the Fantasia he just shows that very nicely.
The keepsakes
The book
Sir Peter Medawar
In that book he starts by saying that one of his friends came to him and said, I understand you're a philosopher. Don't you think that Pluto's Republic is a wonderful thing. What he meant, of course, was Plato's Republic, and he got it all wrong, mistaking the philosopher with Pluto, who is from the Greek mythology, the god of the underworld and death. Peter Medow thought that was really apt, because there must be a Pluto's republic for the intellectual underworld, and that this has many citizens. And then he starts telling you in a very humorous fashion, and critical, of course, about the citizens of Pluto's Republic.
In conversation
Presenter asks
Does the fact that heart transplants are now routine mean you've stopped exploring the limits?
Not at all. Although there has been a lot of improvements and achievements in the transplantation field, there are still a lot of problems and a lot of areas which need to be explored, which are currently being explored. Problems like what we call chronic rejection and that the hearts develop a degree of coronary disease. So there is narrowing of the coronaries again. There are tumors, there could be cancer, there are rejection, infections. All right, it's not very common, but it needs to be eradicated.
Presenter asks
Can you trace the origin of your ambitions to be a heart surgeon?
Almost as far as I remember, I wanted to be a doctor. My father was a doctor and I identified a lot with him. And I said almost jokingly that I'm going to be a surgeon. Probably a heart surgeon or a brain surgeon and my father opposed me and said 'You'll never make that. No, A. It's not a very good life, you can see it how I'm struggling all the time and b You almost certainly I'm not suited for it.'
The recording
Timestamps play the recording from that turn
Speaker 2
Hello, I'm Kirsty Young, and this is a podcast from the Desert Island Discs archive. For rights reasons, we've had to shorten the music.
Speaker 2
The programme was originally broadcast in nineteen ninety five, and the presenter was Sue Lawley.
Presenter
My castaway this week is a surgeon. Born in Egypt sixty years ago, he's recognized as one of the great pioneers of heart transplant surgery in this country. It's a position that has not been achieved without enormous controversy. Some of his experiments, such as when he kept a child alive by connecting him to a baboon, provoked public outcry. But these days his heart transplant operations enjoy a 90% success rate. If you don't want to do anything experimental, he said, you don't want to do anything new. You have to keep exploring the limits. He is Sir Magdi Yakou.
Presenter
You could almost say these days, Professor Yacoub, that that heart transplants are are routine. Does that mean that in a sense you've stopped exploring the limits?
Sir Magdi Yacoub
Not at all. Although there has been a lot of improvements and achievements in the transplantation field, there are still a lot of problems and a lot of areas which need to be explored, which are currently being explored. Problems like what we call chronic rejection and that the hearts develop a degree of coronary disease. So there is narrowing of the coronaries again. There are tumors, there could be cancer, there are rejection, infections. All right, it's not very common, but it needs to be eradicated.
Presenter
So when it's said that you have a ninety percent success rate, what's that mean?
Sir Magdi Yacoub
The ninety percent is in a subset of patients who have ideal characteristics. Sicker patients have anything like eighty percent or s sometimes even seventy percent.
Presenter
But what does that mean that they live for a while?
Sir Magdi Yacoub
That means that at the end of one year, eighty to ninety percent of the patients are alive, but they have a five-year chance of survival of something like sixty-five percent and a ten year of around fifty-five percent.
Presenter
Is there an age limit? Is there an age after which you would not give someone a transplant?
Sir Magdi Yacoub
The problem is the availability of donor organs and the competition between people on the waiting list and the age plays a very major role because you will always tend to give the heart to a younger individual. So we say that it is not practical now.
Sir Magdi Yacoub
to accept people over the age of sixty or sixty five sometimes, unless they are in a very good shape and they are going to improve dramatically to make use of this very, very rare resource.
Presenter
Let's just pause there for a moment and tell me about the first record that you'd like to take to this desert island.
Sir Magdi Yacoub
I would like to take.
Sir Magdi Yacoub
Buquen from the well-tempered Glavier.
Sir Magdi Yacoub
By Johann Sebastian Bach.
Sir Magdi Yacoub
I find the music of Bach very, very soothing, and it sounds very, very simple, and yet it's absolutely perfect in every way, mathematically.
Sir Magdi Yacoub
the structure, the way he puts it together.
Sir Magdi Yacoub
in a simple and masterly way.
Presenter
Prelude and fugue number one from Bach's Well-Tempered Clavier, played by Sviatoslav Richter. Do do you play music in the operating theatre, Professor Joe?
Sir Magdi Yacoub
Yes, we do. I find that very soothing and it uh stops people talking, which I can't stand, uh at least talking irrelevancies, and that sort of creates uh an atmosphere of concentration.
Presenter
So you like silence. You're you're not someone who who, as you say, talks throughout an operation or likes to
Sir Magdi Yacoub
And no, I I I adore silence, I find it a bliss.
Presenter
We were we were talking about your patients. You have one, of course, the uh Derek Morris, who's uh Britain's longest surviving heart transplant patient. I think fifteen years ago now you gave him a new heart, didn't you?
Sir Magdi Yacoub
And yes, I think fourteen, fifteen years.
Presenter
And he obviously is important to you, but he was even so at the time because he, I think, was your third transplant operation and the first two had died.
Sir Magdi Yacoub
That's correct. Derek is very important for more than one reason, because uh he he is an ideal patient in more than one way, because he sort of very meticulous and has uh made use of the operation, if you like, of the improvement in that he continued to do his own thing. He has carried on to do his job. He is a sort of a
Sir Magdi Yacoub
A model face in which people look at and sort of admire.
Presenter
It does seem to me, reading about you, that you go out of your way to to to learn about your patients, to find out what makes them tick, to to tell them to take a holiday, to tell you about their problems.
Sir Magdi Yacoub
I I t I try. I don't always succeed because of limitations of time sometimes, but I try and I love it. It is important to have that rapport and that could help the patient physically by having a positive attitude, for example. That sometimes is a very important factor which can help the patient recover.
Presenter
Yeah.
Presenter
There there have been other stories, too, of of your giving your own blood to a patient during the course of an operation or or sitting next to a baby struggling for life in an incubator and again giving your blood. Those are true, those stories, are they?
Sir Magdi Yacoub
Yeah, I d I don't think that that is uh anything unusual because I think giving blood is a duty almost.
Presenter
But inevitably
Presenter
I think you you you will agree you you've been criticised for it. Your colleagues feel that you're crossing the line, you're becoming emotionally involved with your patients.
Speaker 4
Hmm.
Sir Magdi Yacoub
Uh
Sir Magdi Yacoub
Maybe that that is true, but I I think while a doctor should be rational and uh detached in some way to be able to do absolutely the right thing at the right time, you cannot deny the fact that everybody is not a machine, and you cannot suddenly say, I don't have any emotions and I'm going to be a machine. So a mixture of the two, I don't think, does any harm.
Presenter
Tell me about your second record.
Sir Magdi Yacoub
The second record is by Bob Marley. No Woman, No Cry uh is one of my favorites. I I didn't understand Bob Marley initially and it was my son who was playing Bob Marley and I
Sir Magdi Yacoub
It took me some time uh to understand this music and then when I did, I found that uh it's an extremely sensitive person with lovely music which tackles a lot of human issues.
Speaker 4
No, no man look like
Speaker 4
No warm mind, no cry.
Speaker 4
No, won't mine no
Presenter
Bob Marley and No Woman, No Cry. Can you trace the origin of your ambitions to be a heart surgeon, Professor Yacoup? Was there a moment in your early life when you said, That's what I'm going to be?
Sir Magdi Yacoub
Almost as far as I remember, I wanted to be a doctor. My father.
Sir Magdi Yacoub
or the doctor and
Sir Magdi Yacoub
I identified a lot with him.
Sir Magdi Yacoub
And I said almost jokingly that I'm going to be a surgeon.
Sir Magdi Yacoub
Probably a heart surgeon or a
Sir Magdi Yacoub
brain surgeon and my father
Sir Magdi Yacoub
opposed me and said
Sir Magdi Yacoub
You'll never make that. No, A. It's not a very good life, you can see it.
Sir Magdi Yacoub
how I'm struggling all the time and b
Sir Magdi Yacoub
You
Sir Magdi Yacoub
Almost certainly I'm not suited for it.
Presenter
And then um his sister, your aunt, died when you were quite young, didn't she? And that that had a quite a profound effect on you.
Sir Magdi Yacoub
Yes, his younger sister, who was at the time twenty two.
Sir Magdi Yacoub
died during childbirth from
Sir Magdi Yacoub
a narrowing of one of the heart valves, the mitron valve.
Sir Magdi Yacoub
an eminently correctable condition.
Presenter
Correctable even then.
Sir Magdi Yacoub
Even then, there were a few people who would open that valve and cure the condition.
Presenter
So was that the point, really, at which you thought, this is what I'm going to do?
Sir Magdi Yacoub
I think that was another factor which sort of uh strengthened my resolve.
Presenter
This was all um in in Egypt. You you lived outside Cairo, what some?
Sir Magdi Yacoub
Uh yes. We lived in many parts of Egypt because uh my father had to go wherever there was a need for a surgeon, whether it's in a small town in the south or in Cairo or
Sir Magdi Yacoub
Some of the villages and so on.
Presenter
But eventually after you'd studied at Cairo University, you came to Britain to work, didn't you? Early sixties, I think it was. And obviously those were the years leading up to the point when Christian Barnard in nineteen sixty seven was to perform the world's first heart transplant.
Sir Magdi Yacoub
Um
Presenter
Was there an air of anticipation of that? Was it an exciting time? Did you feel in in the heart feel that something was going to happen?
Sir Magdi Yacoub
Yes, indeed.
Sir Magdi Yacoub
I think
Sir Magdi Yacoub
Transplantation
Sir Magdi Yacoub
Of the heart is an idea and like many ideas they just mature.
Sir Magdi Yacoub
But it was exciting all the same to know that it has now entered the clinical arena, that you can do it in people.
Presenter
And did that make you even more determined that you were going to do it too?
Sir Magdi Yacoub
Yes, indeed.
Presenter
Tell me about record number three.
Sir Magdi Yacoub
Record number three is from Mozart's Requiem, The Confidantes. The whole of the Requiem, Mozart's Requiem is is is wonderful. It's an incredible piece of music. It's perfection again.
Sir Magdi Yacoub
And the confitante is representing this terrific agitation of the soul or something which only Mozart can depict.
Sir Magdi Yacoub
with such brilliance.
Presenter
Part of the confutatis for Mozart's Requiem with the Vienna Philharmonic and State Opera Chorus, conducted by Istvan Kertes.
Presenter
You came back, Magda Yakoub, from Chicago in nineteen sixty nine to this country and to Harefield Hospital in Middlesex, where you've been ever since. But you came, presumably, then because it gave you licence to run your own show. You could set up a transplant programme and do it how you wanted to do it.
Sir Magdi Yacoub
I came back for a variety of reasons. One is what you say is to run a show and again transplantation was not the only thing. There was o other things like, but
Sir Magdi Yacoub
pediatrics and other types of heart surgery, but also because of identify very strongly with the concept of uh the NHS.
Sir Magdi Yacoub
I think it's a marvelous system. Yes, it has a lot of problems and deficiencies which need to be corrected, that's for sure. It's not perfect, but what is. But it is the nearest you can get.
Sir Magdi Yacoub
to perfection. Sometimes I think
Sir Magdi Yacoub
The British public don't realize what an asset this is and how important it is to preserve it, strengthen it and get it to a very high level.
Presenter
Do you think it's being preserved and strengthened at the moment?
Sir Magdi Yacoub
I d I don't know. I think that uh there are attempts at strengthening it, but uh there are some negative forces as well, and hopefully the good will win.
Presenter
It must, though, going back to the seventies now, it must have been.
Presenter
Quite a blow for you, nevertheless, and I'm sorry to harp on about transplants, but obviously this was the the dramatic end of your business. Because suddenly in nineteen seventy three the Department of Health banned them, didn't it? It said they couldn't happen. And indeed they remained banned for six years.
Sir Magdi Yacoub
Yes, indeed, that happened because there is an opportunity uh to force an issue, to say that this is something which can be done and should be done, but then many people do it without preparing, like what happened in many centers, the results were less than optimal and that created a a bad atmosphere.
Presenter
Do you do you think you were partly to blame for that atmosphere and that ban? Because in nineteen seventy three you operated without much warning, didn't you, on on a patient uh and gave him a new heart?
Sir Magdi Yacoub
Yes, you could say that, but uh it is these attempts which force the pace and have made people think harder and try harder to develop new drugs, new knowledge.
Presenter
But at the time the result of I mean, of course, as you say, that's what experimentation does, but at the time what it forced was a ban on the work that you so desperately wanted to do. That must have been very frustrating for you, those six years.
Sir Magdi Yacoub
Yes. On the other hand, I had so many other things to be worrying about at the time, so I waited for the opportunity to come back into that field and that happened.
Presenter
Six years later, as we shall hear. But um tell me about your next record first, number four.
Sir Magdi Yacoub
That also comes from Mozart's Requiem, and it is the lacrymosa which follows immediately after the previous piece of music and provides a contrast, because this is a very
Sir Magdi Yacoub
Peaceful.
Sir Magdi Yacoub
Thoughtful piece of music.
Presenter
Part of the Lacrymosa from Mozart's Requiem, again with the Vienna Philharmonic and State Opera Chorus conducted by Istvan Kertes. You hit the headlines on several occasions during that period in the 70s, during the band Magda Jacob. Once when you connected a child, a thirteen month old, I think, to a live baboon. Can you explain what you did and why you did it?
Sir Magdi Yacoub
At that time
Sir Magdi Yacoub
It was shown by some investigators that if you cool a primate, specifically the papoon,
Sir Magdi Yacoub
and then exchange take all his blood out, and put human blood, and then re warm that animal that the animal would live happily the blood will not reject the other organs, and vice versa.
Sir Magdi Yacoub
This will continue for a period of several weeks. During that period you can connect that animal to a human where the blood is compatible. If you do that,
Sir Magdi Yacoub
You provide a multi-organ support. This has been done to provide support for failing livers. What I did was just an extension of that concept because I had this beautiful baby who had one chambered heart, had some sort of a correction, and was doing well, and then the heart failed, but also several other organs failed. His brain, however, did not. And that was a very strong stimulus for me to think that if I connect that baby
Sir Magdi Yacoub
Two.
Sir Magdi Yacoub
a bamboo treated in the fashion I've just mentioned.
Sir Magdi Yacoub
that that can pro provide multi-organ support.
Presenter
So so the baboon is effectively a a a living heart, lungs and kidney machine.
Sir Magdi Yacoub
The heart, kidney, liver, everything, yeah.
Presenter
sedated, lying alongside the child and fulfilling all the organic functions.
Sir Magdi Yacoub
Yeah.
Sir Magdi Yacoub
Correct. And the the the jaundice disappeared. The heart dis of the baby improved for a period of time. All the organs it started the kidneys of the child started to work.
Presenter
So scientifically it it was completely sound. What about ethically? Did you have any ethical dilemma about that?
Sir Magdi Yacoub
Yes, I felt at the time, and I feel now that there are certain animals who are breeding too fast, and the baboon comes under that heading because there are too many. There aren't there's no way we can use uh an animal who threatened like the higher primates. But baboons, I thought that they can be used on one condition, and that is that we should respect their needs.
Presenter
But as I understand your position as far as the the child, the human being is concerned, and your position applies across the board, is very straightforward.
Presenter
If there's a chance of saving a life, it's perfectly proper to do so as long as it doesn't put another life in danger.
Presenter
Now, what about in the case which occurred, I think, in the mid eighties when you used the heart from a baby born with a malformed brain and you transplanted it into a baby with a heart defect? Uh there was a lot of controversy over that, wasn't there? I mean it it was said that that that you kept alive the donor baby in order to take its heart.
Speaker 4
Yeah.
Presenter
And and it I think was a police investigation in the end, wasn't there?
Sir Magdi Yacoub
Correct. I mean it it it started anyway. Yeah. Yeah, the problem is very emotive stuff. It is indeed, but it depends what you mean by alive.
Presenter
To a
Presenter
Very emotive stuff.
Sir Magdi Yacoub
If I lose my brain.
Sir Magdi Yacoub
Or I'm born without it.
Sir Magdi Yacoub
I am not alive. I don't think you can say that that baby was alive. It's the word alive.
Presenter
Of course the baby connected to the baboon died in the end, didn't he?
Sir Magdi Yacoub
Yes, indeed.
Presenter
And the baboon died too, poisoned by the baby.
Sir Magdi Yacoub
The baboon, yeah, but it wasn't inevitable.
Sir Magdi Yacoub
that either the baboon or the baby will die. I mean, th if this is was is to be repeated.
Sir Magdi Yacoub
A hundred times I'm sure you'll get away with it in eighty, ninety percent.
Presenter
And you'd do the same thing again tomorrow.
Sir Magdi Yacoub
Do the same thing again tomorrow. Do the same again tomorrow. I didn't expect.
Sir Magdi Yacoub
the the outcry which happened afterwards and I would still defend that action.
Presenter
Next piece of music.
Sir Magdi Yacoub
Um the next piece of music is the dance of the swans from Tchaikovsky's Swan Lake. Tchaikovsky is again a very sensitive musician and he created this music with three or four dancers dancing and that to me represents human elegance in a very big way.
Presenter
The Dance of the Swans from Tchaikovsky's Swan Lake with the Vienna Philharmonic conducted by James Levine.
Presenter
You've tried very hard, Professor Jacob, during the course of all of this pioneering work to keep a low profile yourself on the personal level, which hasn't been easy because, as we've discussed, it's all been so controversial. Why are you so shy about having a public profile?
Sir Magdi Yacoub
What I feel is the the issues which are being addressed at any one time.
Sir Magdi Yacoub
Can be confused.
Sir Magdi Yacoub
Well
Sir Magdi Yacoub
The people who are involved.
Presenter
You also prefer to get on with your work, I presume.
Sir Magdi Yacoub
That's that's one
Presenter
Not to be interviewed all the time. But you accepted a knighthood a few years ago. And obviously your your work has brought you material rewards, f fast Italian cars, I'm told, at which you fall asleep at the wheel, is that right?
Presenter
And uh and houses abroad and so on. Do you have time to enjoy all of these things, or are you always working?
Sir Magdi Yacoub
No, I I try and balance my life as much as possible, but sometimes it's difficult.
Presenter
You still make appointments, I understand, to see patients at two o'clock in the morning,'cause that's the only time you've got free.
Sir Magdi Yacoub
Sometimes, yeah. Not often, I hope.
Presenter
And
Presenter
But I mean you come here today having performed an operation in the early hours of the morning because yours is simply a an unpredictable profession, obviously.
Sir Magdi Yacoub
Yes, indeed.
Presenter
And how do you cope with that? I mean, do you manage to live a healthy life, nevertheless?
Sir Magdi Yacoub
My wife is uh
Sir Magdi Yacoub
very strict about that. She tries very hard to make me do all the right things and to swim and every morning and to walk and to do this and that.
Sir Magdi Yacoub
I object sometimes, but I end up
Sir Magdi Yacoub
I enjoyed it.
Presenter
But d do you drink? Do you smoke?
Sir Magdi Yacoub
Um I drink socially.
Sir Magdi Yacoub
I don't smoke. I did, or sometimes even now, smoke a pipe every now and then, but hardly.
Presenter
And I also understand that when you go on holiday, you don't fully relax because you're constantly ringing up to find out how your patients are doing.
Sir Magdi Yacoub
Yeah, but but that's the way of life. Uh you tend to
Sir Magdi Yacoub
accept and live with it.
Presenter
You're said to be unflappable. Do you think you are?
Sir Magdi Yacoub
I try to. I'm not sure how successful I am, but I try.
Presenter
You have an inner calm.
Sir Magdi Yacoub
Uh yes, I again try and uh make it a real thing. It's not always infallible.
Presenter
But that's why you find silence bliss and why you like very precise and mathematical music, is it? You
Presenter
You like a sense of order, or you try to bring a sense of order into yourself.
Sir Magdi Yacoub
So maybe that's the case, yes.
Presenter
Next piece of music.
Sir Magdi Yacoub
The next piece of music is from Saint Matthew Passion, and it is uh the last chorus translated into English. It is uh With tears of grief we leave you dear and I've listened to it many times before, but on one occasion uh in a local church well I I heard my own daughter
Sir Magdi Yacoub
singing in the choir.
Sir Magdi Yacoub
I was so moved that that piece of music has just stuck in my mind and will forever.
Speaker 4
Oh, Spirit Man.
Presenter
The final chorus from Bach's Saint Matthew Passchen Wesetzen und Smittreinen Lieder with the Chicago Symphony Orchestra and Chorus conducted by Sir George Schulte.
Presenter
How far off, Professor Jacob, do you think the invention of the artificial heart is of something small enough and powerful enough?
Presenter
as the heart is to pump blood round the body for twenty four hours a day.
Sir Magdi Yacoub
That's the
Sir Magdi Yacoub
There are devices now.
Sir Magdi Yacoub
which can support life for up.
Sir Magdi Yacoub
To one or two years.
Sir Magdi Yacoub
And that period could be lengthened, but it hasn't got the finesse.
Sir Magdi Yacoub
of a biological system.
Sir Magdi Yacoub
Which is just incredible, it's so superior.
Sir Magdi Yacoub
to anything.
Sir Magdi Yacoub
Man can make.
Sir Magdi Yacoub
But
Sir Magdi Yacoub
The interesting thing is that now
Sir Magdi Yacoub
With the aid of molecular biology, you can control biological processes or you can have a hybrid whereby you have
Sir Magdi Yacoub
Genes.
Sir Magdi Yacoub
doing things for you.
Sir Magdi Yacoub
in an artificial fashion, if you like.
Sir Magdi Yacoub
And
Sir Magdi Yacoub
Perhaps also what is coming.
Sir Magdi Yacoub
is manipulating organs from other species to make them compatible with man.
Presenter
So if man can't invent the heart a heart himself, he can actually find a way round it, do you think?
Sir Magdi Yacoub
Correct. Correct.
Presenter
Record number seven.
Sir Magdi Yacoub
I would like to take with me Schubert's serenade, a lot of Schubert's music.
Sir Magdi Yacoub
Um is very, very emotional and beautiful and flowing.
Sir Magdi Yacoub
And I find his serenade.
Sir Magdi Yacoub
As representative of that
Sir Magdi Yacoub
Extremely beautiful attribute.
Speaker 4
Thies a free and minor leader.
Speaker 4
Horace North.
Speaker 4
Mr Trank have been the rouchen In a small sleek in a small
Speaker 4
The sparrow spine twitched all shall fear the war.
Presenter
Fritz Bunderlich singing Schubert's Serenade. What about Magdy Jacob on a Desert Island? Do you think you could organize yourself practically and domestically for this kind of Robinson Crusoe existence?
Sir Magdi Yacoub
I am not a very organized person.
Sir Magdi Yacoub
Uh when it comes to everyday life, um I'm blessed with people who try and organize me.
Presenter
But otherwise you create chaos, do you?
Sir Magdi Yacoub
Because otherwise
Sir Magdi Yacoub
Yeah, that's what worries me, yes.
Presenter
But is is there again contemplating a desert island existence is there part of you that that longs for that kind of peace? Or are you hooked in many ways on the pressure of your work?
Sir Magdi Yacoub
No, I think uh I am hooked on my work to some extent, but uh I still long for the idea of being
Sir Magdi Yacoub
on my own, interacting with nature, I think it doesn't frighten me somehow.
Presenter
And what about in real life? You're sixty later this year. Do you contemplate retirement?
Sir Magdi Yacoub
I don't think about it. I still am totally immersed in my work and uh
Sir Magdi Yacoub
But there are things in life I I would want to do.
Presenter
What do you want to do?
Sir Magdi Yacoub
Um I want to uh
Sir Magdi Yacoub
a farm, for example, or grow flowers or that would uh be something which could
Sir Magdi Yacoub
Absorbed me very much.
Presenter
You grow orchids, don't you?
Sir Magdi Yacoub
I I do, yeah.
Presenter
Award-winning orchid.
Sir Magdi Yacoub
Well, I don't know. I I haven't entered competitions, but some of the flowers could be, but I haven't.
Sir Magdi Yacoub
in that competitive life in that field.
Presenter
By the way, did your did your father live to see you fulfil your ambition?
Sir Magdi Yacoub
No, my father died just before.
Sir Magdi Yacoub
I came to this country.
Sir Magdi Yacoub
He uh had a heart attack and died.
Sir Magdi Yacoub
That was quite sad.
Presenter
Mas record.
Sir Magdi Yacoub
The last record is Mozart's Fantasia for piano.
Sir Magdi Yacoub
Mozart has many facets as we have heard, but at times he can be very thoughtful and I think that in the Fantasia he just shows that very nicely.
Presenter
Part of Mozart's Fantasia for piano in D minor played by Emile Guillels. If you could only take one of those records, Professor.
Sir Magdi Yacoub
I think it's going to be very difficult to choose, but I think I'll ti take them outside.
Presenter
What about your book?
Sir Magdi Yacoub
I think I'll take a book by the late Sir Peter Medawa, Pluto's Republic.
Sir Magdi Yacoub
And in that book he starts by saying that.
Sir Magdi Yacoub
One of his friends came to him and said, I understand you're a philosopher. Don't you think that Pluto's Republic
Sir Magdi Yacoub
is a wonderful thing. What he meant, of course, was Plato's Republic, and he got it all wrong, mistaking the uh philosopher with Pluto, who is from the Greek Greek mythology, the god of the underworld and death.
Sir Magdi Yacoub
Peter Medow thought that was really apt, because there must be a Pluto's republic for the intellectual underworld, and that this has many citizens. And then he starts telling you
Sir Magdi Yacoub
In a very humorous fashion, and critical, of course, about the citizens of Pluto's Republic.
Presenter
Yeah.
Presenter
What about your luxury?
Sir Magdi Yacoub
I think I'll take a hammock.
Sir Magdi Yacoub
To listen to my music or read the books.
Sir Magdi Yacoub
Uh that would be my luxury.
Presenter
Professor Sir Magdi Yakub, thank you very much indeed for letting us hear your desert island discs.
Sir Magdi Yacoub
Thank you.
Speaker 2
You've been listening to a podcast from the Desert Islandists archive. For more podcasts, please visit bbc.co.uk slash radio four.
Presenter asks
Can you explain what you did with the baboon and why?
At that time it was shown by some investigators that if you cool a primate, specifically the baboon, and then exchange take all his blood out, and put human blood, and then re warm that animal that the animal would live happily the blood will not reject the other organs, and vice versa. This will continue for a period of several weeks. During that period you can connect that animal to a human where the blood is compatible. If you do that, you provide a multi-organ support. This has been done to provide support for failing livers. What I did was just an extension of that concept because I had this beautiful baby who had one chambered heart, had some sort of a correction, and was doing well, and then the heart failed, but also several other organs failed. His brain, however, did not. And that was a very strong stimulus for me to think that if I connect that baby to a baboon treated in the fashion I've just mentioned, that that can provide multi-organ support.
Presenter asks
Did you have any ethical dilemma about using a baboon?
Yes, I felt at the time, and I feel now that there are certain animals who are breeding too fast, and the baboon comes under that heading because there are too many. There aren't there's no way we can use an animal who threatened like the higher primates. But baboons, I thought that they can be used on one condition, and that is that we should respect their needs.
Presenter asks
Why are you so shy about having a public profile?
What I feel is the issues which are being addressed at any one time can be confused with the people who are involved.
Presenter asks
How far off is the invention of a fully artificial heart?
There are devices now which can support life for up to one or two years. And that period could be lengthened, but it hasn't got the finesse of a biological system. Which is just incredible, it's so superior to anything man can make. But the interesting thing is that now with the aid of molecular biology, you can control biological processes or you can have a hybrid whereby you have genes doing things for you in an artificial fashion, if you like. And perhaps also what is coming is manipulating organs from other species to make them compatible with man.
“I find the music of Bach very, very soothing, and it sounds very, very simple, and yet it's absolutely perfect in every way, mathematically.”
“I adore silence, I find it a bliss.”
“I think giving blood is a duty almost.”
“While a doctor should be rational and detached in some way to be able to do absolutely the right thing at the right time, you cannot deny the fact that everybody is not a machine, and you cannot suddenly say, I don't have any emotions and I'm going to be a machine. So a mixture of the two, I don't think, does any harm.”
“I think it's a marvelous system. Yes, it has a lot of problems and deficiencies which need to be corrected, that's for sure. It's not perfect, but what is. But it is the nearest you can get to perfection. Sometimes I think the British public don't realize what an asset this is and how important it is to preserve it, strengthen it and get it to a very high level.”
“I still long for the idea of being on my own, interacting with nature, I think it doesn't frighten me somehow.”